async function SavePhoto(inp) 
{
    let user = { name:'john', age:34 };
    let formData = new FormData();
    let photo = inp.files[0];      
         
    formData.append("photo", photo);
    formData.append("user", JSON.stringify(user));  
    
    try {
       let r = await fetch('/upload/image', {method: "POST", body: formData}); 
       console.log('HTTP response code:',r.status); 
    } catch(e) {
       console.log('Huston we have problem...:', e);
    }
    
}

<input id="image-file" type="file" onchange="SavePhoto(this)" >
<br><br>
Before selecting the file open chrome console > network tab to see the request details.
<br><br>
<small>Because in this example we send request to https://stacksnippets.net/upload/image the response code will be 404 ofcourse...</small>

<br><br>
(in stack overflow snippets there is problem with error handling, however in <a href="https://jsfiddle.net/Lamik/b8ed5x3y/5/">jsfiddle version</a> for 404 errors 4xx/5xx are <a href="https://stackoverflow.com/a/33355142/860099">not throwing</a> at all but we can read response status which contains code)

function SavePhoto(e) 
{
    let user = { name:'john', age:34 };
    let xhr = new XMLHttpRequest();
    let formData = new FormData();
    let photo = e.files[0];      
    
    formData.append("user", JSON.stringify(user));   
    formData.append("photo", photo);
    
    xhr.onreadystatechange = state => { console.log(xhr.status); } // err handling
    xhr.open("POST", '/upload/image');    
    xhr.send(formData);
}

<input id="image-file" type="file" onchange="SavePhoto(this)" >
<br><br>
Choose file and open chrome console > network tab to see the request details.
<br><br>
<small>Because in this example we send request to https://stacksnippets.net/upload/image the response code will be 404 ofcourse...</small>

<br><br>
(the stack overflow snippets, has some problem with error handling - the xhr.status is zero (instead of 404) which is similar to situation when we run script from file on <a href="https://stackoverflow.com/a/10173639/860099">local disc</a> - so I provide also js fiddle version which shows proper http error code <a href="https://jsfiddle.net/Lamik/k6jtq3uh/2/">here</a>)